Italian Dermal Filler Innovation: L-Proline & Glycine in UPTOURN BDDE Cross-Linked Hyaluronic Acid
In modern aesthetic medicine, patients and practitioners are searching for more than volume replacement. They want dermal fillers that improve skin quality, stimulate collagen, and deliver long-lasting, natural results.
UPTOURN dermal fillers represent this next generation of innovation by combining BDDE-crosslinked hyaluronic acid with L-Proline and Glycine, two essential amino acids crucial for collagen synthesis and dermal regeneration.
This advanced formulation provides immediate structural correction with progressive biological rejuvenation, ensuring results that are durable, natural, and clinically meaningful.
BDDE Cross-Linked Hyaluronic Acid: A Stable and High-Performance Matrix
UPTOURN fillers are manufactured using BDDE (1,4-butanediol diglycidyl ether) cross-linking technology, the gold standard in hyaluronic acid dermal fillers.
BDDE forms stable ether bonds, known for:
- Low toxicity
- High biocompatibility
- Long-term resistance to enzymatic degradation
This process creates a three-dimensional, spiderweb-like hyaluronic acid matrix, a hallmark of premium cross-linked HA fillers.
Proven Rheological Properties for Predictable Clinical Results
From a scientific and clinical perspective, the UPTOURN HA matrix demonstrates:
- Solid-like elastic behavior (G’ > G”) across functional frequencies
- Low tan δ values, indicating strong structural integrity
- Stable viscoelastic performance at body temperature
These rheological properties translate into real-world benefits:
- Predictable lifting capacity
- Excellent shape retention
- Harmonious integration into dynamic facial tissues
Amino Acid Enrichment: The Biology Behind Skin Regeneration
While BDDE cross-linked hyaluronic acid provides mechanical strength, L-Proline and Glycine add a powerful biological advantage that differentiates UPTOURN fillers.
1. Collagen Stimulation and Dermal Renewal
L-Proline and Glycine are primary building blocks of collagen types I and III. Their presence supports fibroblast activity and promotes new collagen formation around the filler, improving skin firmness and dermal density over time.
2. Enhanced Tissue Integration
The amino-acid-enriched extracellular matrix (ECM) encourages smoother blending between the filler and surrounding tissue, reducing irregularities and delivering a more natural look and feel.
3. Long-Lasting Structural Support
By supporting ECM regeneration, L-Proline and Glycine help extend volumizing effects, complementing the chemical longevity of BDDE ether bonds for prolonged aesthetic outcomes.
4. Improved Recovery and Patient Comfort
These amino acids play a role in wound-healing pathways and micro-inflammation modulation, contributing to:
- Gentler injection experience
- Reduced post-treatment discomfort
- Faster recovery
Dual-Action Technology: Structural + Biological Performance
UPTOURN dermal fillers work through two synergistic mechanisms:
Structural Action (BDDE Cross-Linking)
- High elasticity and stability
- Long-lasting volumization
- Strong resistance to deformation
- Predictable performance in dynamic facial areas
Biological Action (L-Proline + Glycine)
- Stimulation of collagen synthesis
- Improvement in skin elasticity and firmness
- Reinforcement of dermal architecture
- Progressive enhancement of skin quality
The result: a dermal filler that not only shapes the face but actively rejuvenates the skin.
Why Practitioners Choose UPTOURN Dermal Fillers
Aesthetic professionals choose UPTOURN for its science-driven formulation and reliable clinical performance, including:
- Natural texture and seamless tissue integration
- Immediate lifting with long-term skin improvement
- Durable results through BDDE-ether stability and ECM support
- Enhanced patient comfort and recovery
- Scientifically validated matrix architecture
UPTOURN delivers the ideal balance of precision, performance, and patient satisfaction.
Summary: Advanced Amino Acid Dermal Filler Technology
UPTOURN dermal fillers combine BDDE-crosslinked hyaluronic acid with L-Proline and Glycine to deliver durable volume, superior elasticity, enhanced collagen regeneration, and improved skin quality.
The unique spiderweb-like HA matrix ensures excellent tissue integration and long-lasting results, while amino acid enrichment supports dermal firmness, regeneration, and post-treatment comfort.